RT/follows do not imply endorsement.

Boston, MA
Joined February 2012
#ICYMI: Vesicular miR-122-5p crosstalks in aortic stenosis @JBMIVPhD @reinier_boon @BIOTECH24GEB #AHAJournals
#OriginalResearch: Circulating microRNA-122-5p is associated with a lack of improvement in left-ventricular function after transcatheter aortic valve replacement and regulates viability of cardiomyocytes via extracellular vesicles #AHAJournals ahajrnls.org/3Rv9zGl
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#ICYMI: TAVR Deformation, HALT, and Outcomes @psorajja @Miho_Fukui_ @MHIF_Heart #AHAJournals
Hypo-attenuating leaflet thickening occured in 16-21% of patients undergoing TAVR and was found to be associated with non-unifrom expansion of #TAVR valves @Miho_Fukui_ @golegguards #AHAJournals ahajrnls.org/3uNGs74
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#ICYMI: SGLT2 and ACE inhibition in T1D #AHAJournals
#OriginalResearch: In this mechanistic trial of patients with #T1DM, addition of #SGLT1i to ACEi resulted in ⬇️ oxidative stress markers, ⬇️ BP, ⬇️ total peripheral resistence and expected dip in GFR, consistent with renoprotective physiology #AHAJournals ahajrnls.org/3aHUPTR
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#ICYMI: A prespecified analysis of DAPA-HF #AHAJournals @UoGHeartFailure
Effect of #dapagliflozin on outpatient worsening treated with intensification of oral therapy in patients with #HFrEF: A prespecified analysis of DAPA-HF. Learn more: ow.ly/gPNk50C35Dx #AHAJournals @Kieranfdocherty @PSJhund @UoGHeartFailure
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#OriginalResearch: A multinational federated learning approach to train electrocardiogram and echocardiogram models for hypertrophic cardiomyopathy detection #AHAJournals ahajrnls.org/3JB2iAV
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#OriginalResearch: The predictive utility of a validated polygenic risk score for long-term risk of coronary disease in young and middle-aged adults.@heartdocsadiya #AHAJournals ahajrnls.org/3df61IE
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#OriginalResearch: Identification of a gain-of-function LIPC variant as a novel cause of familial combined hypocholesterolemia in a cohort of patients in France @Rensen_Lab@yokofakun @AntoineRimbert #AHAJournals ahajrnls.org/3ztMIm0
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#OriginalResearch: Donor macrophages may modulate rejection after heart transplantation @junedh_amrute #AHAJournals ahajrnls.org/3JG4p6Q
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#ResearchLetter vWF may be produced solely in vascular endothelium, limiting the utility of in situ antibody staining to infer cellular lineage of neointimal cells from endothelial cells in PAH @Paul_P_Cheng #AHAJournals ahajrnls.org/3BMUtqg
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#Editorial Lessons learned from #REDUCE-IT on placebo choice, transparency, biosamples in RCTs and mechanisms vs. patient centered outcomes in RCT design #AHAJournals ahajrnls.org/3bApe74
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#Perspective When clinical trials are interrupted by catastrophes, what are the ethical and research concerns and what strategies can be implemented to mitigate them? @JLHarrington_MD @DukeHFDoc @robmentz #AHAJournals ahajrnls.org/3dazof5
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#ICYMI: Exercise-induced cardiomyogenesis in aged hearts @rosenzweig_a @CLerchenmueller @AnaVujic5 #AHAJournals
#OriginalResearch: Voluntary running partially restores #cardiomyogenesis in aged mice and circadian rhythm may play a role in these pathways @CLerchenmueller @lihaobo @CRabolli #AHAJournals ahajrnls.org/3AQPt3s
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#ICYMI: Valvular heart disease in patients with diabetes @goteborgsuni @AidinRawshani @sahlgrenska #AHAJournals
#OriginalResearch: Analysis of Swedish nationwide registry data found patients w/ Type 1 & Type 2 DM have ⬆️ risk for aortic and mitral stenosis, while those with Type 2 DM have ⬇️ risk for valvular regurgitation. New insight into lifelong risk for mitr... ahajrnls.org/3OF5eOm
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#OriginalResearch: In this study of AS patients undergoing #TAVR, MRI showed new cerebral microbleeds in ~1 in 4 individuals. Anticoagulation management & persistent VWF-defect were associated with new microbleeds #AHAJournals ahajrnls.org/39TJWOu
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#ICYMI: REDUCE-IT Trial Biomarker Study @gabrielsteg @DLBhattMD @mmillermd1 #AHAJournals
#OriginalResearch: In this substudy of the REDUCE-IT #RCT, atherosclerotic biomarkers did not change in the icosapent ethyl group but increased over time in the mineral oil comparator group @gabrielsteg @DLBhattMD @mmillermd1 #AHAJournals ahajrnls.org/3axw7pf
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#FromTheLiterature: 1) Whole-Genome Strategy Predicts Common Diseases in Preimplantation Embryos; 2) Artificial Intelligence Tool Detects and Discriminates Amongst Heart Diseases; 3) Local Heat Therapy Activates Beige Fat #AHAJournals ahajrnls.org/3bitmsc
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#ResearchLetter: In the SUGAR-DM-HF trial, #empagliflozin reduced kidney perfusion and kidney volume assessed by MRI in patients with #HFrEF and #T2DM/pre-DM. @MetaMedTeam @UoGHeartFailure #AHAJournals ahajrnls.org/3Q6KjVm
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#InDepth: A comprehensive review of #AF management in #HFrEF and #HFpEF and selective rhythm control in a phenotype-guided approach. @yreddyhf @mayoclinicCV #AHAJournals ahajrnls.org/3BrNliB
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#Editorial: Immune checkpoint inhibitors are life saving therapies for tumors, but may induce #myocarditis. New data published in @CircAHA suggest that CD45RA+ effector memory CD8+ T cells are involved. @kallikourdis @gcondorelli #AHAJournals ahajrnls.org/3bjFs4j
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