physician-scientist, author, editor drerictopol.com
La Jolla, CA
Joined November 2009
- Tweets 42,090
- Following 543
- Followers 643,877
- Likes 42,303
Pinned Tweet
This will go down in history as one of science and medical research's greatest achievements. Perhaps the most impressive.
I put together a preliminary timeline of some key milestones to show how several years of work were compressed into months.
1,803
11,419
2,090
40,211
In the United States, 136,000 new confirmed cases today brings the 7-day average >100,000. Real number is esitmated to be ~700,000. And >500 more people hospitalized. No reason for concern, right @CDCgov?
charts.medriva.com/us
erictopol.substack.com/p/the…
31
356
23
932
The "Delta" (L452R) mutation found in both the BA.2.12.1 and BA.4/BA.5 variants is key to both immune escape and enhanced cell fusion (not present in BA.1 or BA.2). And people with prior Delta infections have better neutralization to these variants biorxiv.org/content/10.1101/…
34
191
24
648
The mutation map I attached (not in the preprint) was made from outbreak.info so if there are any questions, here is the link outbreak.info/compare-lineag…
5
11
1
72
The problem with Omicron mild infections escaping both adequate antibody and T-cell response, and vulnerability to reinfections
cell.com/cell-reports-medici… @CellRepMed @Dr_Banika @UniofAdelaide
10
124
8
339
"mRNA vaccines appear superior to adenovirus vector-based vaccines in inducing neutralizing antibodies against VOCs four weeks after initial vaccination
and after booster vaccination"
New @PLOSMedicine
journals.plos.org/plosmedici…
9
77
3
283
"Our results demonstrate that use of live-attenuated
[nasal] vaccines may offer advantages over available COVID-19 vaccines, specifically when applied as
booster, and may provide a solution for containment of the COVID-19 pandemic."
biorxiv.org/content/10.1101/…
nytimes.com/2022/05/16/opini…
48
466
63
1,514
There should be a full court press to move these forward theguardian.com/commentisfre…
16
96
10
498
And T cell vaccines that can be given nasally and achieve mucosal immunity across variants
pnas.org/doi/suppl/10.1073/p… @PNASNews
10
62
4
265
Confirmation of the 2nd booster protection from death in people age 80+ in Sweden, with a relative vaccine effectiveness 42% (compared w/ the 1st booster)
papers.ssrn.com/sol3/papers.…
12
77
7
275
If you think the Omicron outcome dynamics from South Africa predict what will happen in the United States, you're wrong
22
70
2
250
Eric Topol retweeted
"The problem we have is this illusion or deception that the pandemic is over, when, in fact, these variants that we're seeing are coming at a much faster clip. There's an accelerated evolution of the virus," @EricTopol tells @WmBrangham. to.pbs.org/3Pqqokn
26
298
23
531
This essay prompted the discussion I had with @WmBrangham @pbsnewshour this evening
pbs.org/newshour/show/why-th…
6
36
4
160
It's really striking how well trained scent dogs can detect Covid (and #LongCovid): a randomized controlled, triple-blinded validation trial and real life study at in airport. They need to get retrained for diff't variants globalhealth.bmj.com/lookup/… @GlobalHealthBMJ @HelsinkiUniMed
79
614
105
1,843
