physician-scientist, author, editor drerictopol.com

La Jolla, CA
Joined November 2009
This will go down in history as one of science and medical research's greatest achievements. Perhaps the most impressive. I put together a preliminary timeline of some key milestones to show how several years of work were compressed into months.
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In the United States, 136,000 new confirmed cases today brings the 7-day average >100,000. Real number is esitmated to be ~700,000. And >500 more people hospitalized. No reason for concern, right @CDCgov? charts.medriva.com/us erictopol.substack.com/p/the…
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Eric Topol retweeted
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The "Delta" (L452R) mutation found in both the BA.2.12.1 and BA.4/BA.5 variants is key to both immune escape and enhanced cell fusion (not present in BA.1 or BA.2). And people with prior Delta infections have better neutralization to these variants biorxiv.org/content/10.1101/…
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The mutation map I attached (not in the preprint) was made from outbreak.info so if there are any questions, here is the link outbreak.info/compare-lineag…
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The problem with Omicron mild infections escaping both adequate antibody and T-cell response, and vulnerability to reinfections cell.com/cell-reports-medici… @CellRepMed @Dr_Banika @UniofAdelaide
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"mRNA vaccines appear superior to adenovirus vector-based vaccines in inducing neutralizing antibodies against VOCs four weeks after initial vaccination and after booster vaccination" New @PLOSMedicine journals.plos.org/plosmedici…
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"Our results demonstrate that use of live-attenuated [nasal] vaccines may offer advantages over available COVID-19 vaccines, specifically when applied as booster, and may provide a solution for containment of the COVID-19 pandemic." biorxiv.org/content/10.1101/… nytimes.com/2022/05/16/opini…
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And T cell vaccines that can be given nasally and achieve mucosal immunity across variants pnas.org/doi/suppl/10.1073/p… @PNASNews
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Confirmation of the 2nd booster protection from death in people age 80+ in Sweden, with a relative vaccine effectiveness 42% (compared w/ the 1st booster) papers.ssrn.com/sol3/papers.…
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Not as pronounced a booster mortality reduction in the 3 prior studies of people at younger age (lower risk) from Israel
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If you think the Omicron outcome dynamics from South Africa predict what will happen in the United States, you're wrong
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The BA.2.12.1 variant now accounting for 48% new cases in the United States
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Now dominant in Regions 2, 3, 4 and 7
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Why is this transition to BA.2.12.1 important? erictopol.substack.com/p/the…
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Eric Topol retweeted
"The problem we have is this illusion or deception that the pandemic is over, when, in fact, these variants that we're seeing are coming at a much faster clip. There's an accelerated evolution of the virus," @EricTopol tells @WmBrangham. to.pbs.org/3Pqqokn
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It's really striking how well trained scent dogs can detect Covid (and #LongCovid): a randomized controlled, triple-blinded validation trial and real life study at in airport. They need to get retrained for diff't variants globalhealth.bmj.com/lookup/… @GlobalHealthBMJ @HelsinkiUniMed
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