If there is one thing I am going to tell you today it is to IGNORE the media and the clickbait headlines on this new variant. There is NO plausible scenario this will take us back to square one and there is a lot of misinformation currently circulating. Working on a thread now.
1:21 PM · Nov 26, 2021
Just a friendly reminder. Despite what you might hear, there has yet to be a variant that isn’t susceptible to the vaccines. Let’s talk about Nu (B.1.1.529) clear up some misconceptions, and talk about why it is unlikely it will evade vaccine-induced immunity. 🧵
Why are variants unlikely to FULLY evade vaccine-induced immunity? •Vaccines are POLYCLONAL •CD8+ T-cells covering 52 epitopes across the spike protein •CD4+ T-cells covering 23 epitopes across the spike protein For more on this see: science.org/doi/10.1126/scie…
So, let’s get a couple of things straight NO ONE knows if it is more transmissible at this point. Seeing “Nu is 500% more transmissible” with no data and maybe a bad interpretation of a graph? Yeah, someone is yanking your chain. Also it is NOT a new virus, it is A VARIANT of the
same SARS-COV-2 virus we have been dealing with for almost 2 years now. Stop that. Give me a break. To those saying it is “outcompeting” Delta. Important thing to keep in mind: there hasn’t been much Delta to displace or “outcompete.” Until last week, South Africa was at its
lowest incidence rate since the beginning of the pandemic. In other words, the low incidence of Delta in South Africa kinda means that Nu becoming dominant is weaker evidence of it “outcompeting” it when there really wasn’t much to outcompete so to speak.
You can see for yourself here. With relatively low cases, this may left a void which a new variant could spread into more easily- it likely hasn't had to compete with Delta and in other countries where Delta rages on, it very well may not be as fit.
Vaccine equity is vital. Variants pop up out of low vaccinated areas. Immune evasion may not be needed to spread and fitness could EASILY differ in higher-vaccinated countries, and those dominated by Delta. I also recommend reading this thread here:
People are asking what I think about the B.1.1.529 variant that is rapidly increasing in frequency in South Africa. It certainly merits close monitoring. That said: I believe the hockey-stick graphs from yesterday are in error. We are nowhere near the delta peak prevalence.Show this thread
In regards to those who were infected with Nu, some data has come out regarding the status of some individuals, specifically out of Hong Kong. Vaccinated fully with Pfizer back in May/June, the individual is currently ASYMPTOMATIC. You can read more here:
Also important to note. nitter.fdn.fr/nzm8qs/status/14… In Hong Kong hospitalization DOES NOT translate into severity, as anyone tested positive is to be hospitalized. He’s asymptomatic and in the hospital due to protocol. Fully vaccinated in the spring. That’s a decent sign.
This Tweet is unavailable.
These vaccines are polyclonal, there are non-neutralizing antibodies, and T-CELLS. Will the vaccines take a hit? Likely. as they do with ALL variants. Will it completely render these useless? Absolutely not. For those saying Nu decimates these vaccines to 30% efficacy? Stop that.
TLDR: YES, we need more data. NO, we are NOT going back to square one. The BEST thing you can do right is to GET VACCINATED. GET THE WORLD VACCINATED. GET BOOSTED, it not only restores it EXCEEDS. It is time we stop tripping up over our own feet. This DOESN’T need to be so hard.