SARS2 and HIV-1 redux In Feb of 2020, a preprint showing that the SARS2 spike protein has 4 regions of homology with HIV-1 (bit.ly/3rmBtYD) was forced to retract. So where are these regions in the 3D protein structure? 馃槻All 4 regions are missing! Surgically ...
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Missing residues usually indicate flexible loops. So where are these loops? What are they doing? The first 3 are from the HIV-1 gp120 gene which allows it to bind to host cells containing the CD4 receptor: mostly immune cells like T-cells and macrophages. O no, what if ...
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Someone alerted Fauci to the same problem: bit.ly/3qtU06e What if the spike protein can interact with the CD4 receptor? Bad news. Here are the regions in the structure. Spike forms a homo-trimer. The regions (red, yellow, and blue) come together at a peripheral point.
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Below is a zoomed-in version for subunit A, with the 3 missing loops drawn in by hand. Note how close their connectors (shown as solid spheres) are in 3D. So 3 regions with homology to the CD4 binding domain of HIV-1: - are missing in the structure - come together in 3D

Jan 15, 2022 路 10:46 PM UTC

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Should we conclude that the SARS2 spike protein can interact with CD4? Of course not If the powers-that-be hadn't forced the retraction of the preprint, we would have had an answer by now Interestingly, #Fauci knew about this in Feb 2020: bit.ly/3qtU06e Who alerted?
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There is already evidence that SARS2 can affect CD4+ T helper cells, lymphocytes that coordinate the adaptive immune response. Thank you @Rossana38510044 ! bit.ly/3FEuJe0
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Replying to @tony_vandongen
What do you mean "missing in the structure?" Either they are there or they aren't. You can't just draw stuff on top. Is the sequence there to produce these structures or isn't it?