SARS2 and HIV-1 redux In Feb of 2020, a preprint showing that the SARS2 spike protein has 4 regions of homology with HIV-1 (bit.ly/3rmBtYD) was forced to retract. So where are these regions in the 3D protein structure? 😲All 4 regions are missing! Surgically ...
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Missing residues usually indicate flexible loops. So where are these loops? What are they doing? The first 3 are from the HIV-1 gp120 gene which allows it to bind to host cells containing the CD4 receptor: mostly immune cells like T-cells and macrophages. O no, what if ...
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Replying to @Daoyu15
Thank you Daoyu, that is very interesting. Do you think the 3 flexible loops ion the SARS2 Spike form a CCR5 binding site?

Jan 16, 2022 · 8:21 PM UTC

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Replying to @tony_vandongen
the loops on HIV forms the CCR5 binding site. they are spatially clustered on the same location on the S NTD. they are not evolutionarily favored.
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And at this point we don't know what the function is of the these 3 loops in the SARS 2 spike protein, correct? I am surprised nobody has modeled those loops, other than the (redacted) person who emailed Fauci to tell him they it formed a CD4 binding site:
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