Welcome to the RNA networks lab! @TheCrick and @UCL in London and @kemijski in Ljubljana 🇪🇺

Joined August 2020
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How does TDP-43 condensation influence its RNA binding specificity? Fantastic to finally share this labour of love with the community - congratulations @martinahallegg1 @fcylee @am_chakrabarti!!
Enormously proud of the result of this amazing collaboration with @am_chakrabarti, @fcylee, @luslab, @ShorterLab, @Nicolas_Fawzi and @PataniLab on how TDP-43 condensation specifies RNA binding and regulation now published in @CellCellPress authors.elsevier.com/sd/arti…
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TODAY, 12h, for our #CEDOCSeminar we will have @PauloGameiro8 from @ule_lab @TheCrick to talk about "Metabolism & RNA modifications in gene regulation". 🧑‍🔬👨‍🏫 Don't miss it! DM us for the Zoom link 📬🙌
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ule_lab retweeted
@ule_lab jbc.org/article/S0021-9258(2… Latest, a 13C-based assay to quantify the turnover of base modifications in newly transcribed RNA, by mass spectrometry. We uncover the origin of RNA modifications in digested RNA, and assess their sensitivity to metabolic stresses.
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After an extremely long time, members of @ule_lab are enjoying an in-person conference in Vienna @viennabiocenter. What a feeling! 🤗 @paraspeckle @martinahallegg1
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Thanks to Flora, CLIP has become now even more accessible. iiCLIP enables quality control and optimisation via non-radioactive analysis protein-RNA complexes to produce data of high specificity.
Very happy to share our @biorxivpreprint on an improved iCLIP protocol (iiCLIP) and benchmarking from @ulelab! biorxiv.org/content/10.1101/…
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ule_lab retweeted
Condensates on transposon(-derived) transcripts and regulation of TDP43-RNA interactions. exciting Transposon-RNA biology by Jernej Ule #EMBOMobileGene
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ule_lab retweeted
🗨️ "Coming from a background in fundamental research, I was thrilled to apply this skill set to some foundational questions in the field of motor neurone research." Find out more about @martinahallegg1's work and the value of @mndassoc support ⤵️ mndresearch.blog/2021/06/24/…
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So glad that the @ShorterLab could lend their expertise to this joint effort!
TDP-43 condensation properties specify its RNA-binding and regulatory repertoire, excited that this collaborative work with @martinahallegg1 @ule_lab @Nicolas_Fawzi @JackRubien @YSPTSPS et al. is out in @CellCellPress: cell.com/cell/fulltext/S0092…
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Delighted to share our streamlined protocol and software for Cas9-mediated depletion of unwanted sequences with the Ribo-seq community! Of course if you have troublesome sequences in your iCLIP/miCLIP/eCLIP/[etc...]CLIP libraries you can use it for that too!
Our super speedy and effective protocol for removing unwanted rRNA from Ribo-seq (or similar) libraries is out on BioRxiv! biorxiv.org/content/10.1101/…
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We would like to update everyone on the current availability of our free iMaps platform for CLIP data analysis and our exciting future plans! 1/6
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Firstly, the current iMaps platform imaps.genialis.com/iclip will continue to run with full functionality until the end of September 2021. We recommend continuing to use this platform until then. 2/6
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Secondly, we are actively developing iMaps v2 with @goodwright_ imaps.goodwright.org/ - this platform will have several improvements, including a Nextflow backend based on nf-co.re/clipseq/1.0.0 3/6
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We have also created a Slack workspace so that you can give feedback on the new platform and future developments. join.slack.com/t/imapsgroup/… 4/6
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The workspace also has a channel to ask questions about CLIP generally, which are then collated on our Q&A CLIP Forum docs.imaps.goodwright.org/ 5/6
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We hope you find these resources useful & if you have any questions and suggestions, or wish to contribute and join forces, please do get in touch! 6/6
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ule_lab retweeted
Congratulations to Dr @JulieQLin, a Research Fellow of Clare Hall, who has been recognised as an Emerging Leader in #dementia research by @UKDRI. Learn more via our news story 💡⬇ clarehall.cam.ac.uk/news/08-… #clarehallcam
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We are excited to be hosting a hybrid mini-symposium in late August "A Journey Through RNA Space and Time" - free registration is open now! jtrst.conference.so/
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